Radiotherapy & Oncology
Volume 92, Issue 1 , Pages 34-41 , July 2009

A randomised controlled trial of forward-planned radiotherapy (IMRT) for early breast cancer: Baseline characteristics and dosimetry results

  • Gillian C. Barnett

      Affiliations

    • Department of Oncology, University of Cambridge, Cambridge, UK
    • Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • ,
  • Jennifer Wilkinson

      Affiliations

    • Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • ,
  • Anne M. Moody

      Affiliations

    • Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • ,
  • Charles B. Wilson

      Affiliations

    • Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • ,
  • Ravi Sharma

      Affiliations

    • Department of Oncology, Aberdeen, UK
  • ,
  • Sabine Klager

      Affiliations

    • Research and Development Office, Institute of Child Health (UCL) and Great Ormond Street Hospital for Children NHS Trust, London, UK
  • ,
  • Andrew C.F. Hoole

      Affiliations

    • Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • ,
  • Nicola Twyman

      Affiliations

    • Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  • ,
  • Neil G. Burnet

      Affiliations

    • Department of Oncology, University of Cambridge, Cambridge, UK
  • ,
  • Charlotte E. Coles

      Affiliations

    • Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    • Corresponding Author InformationCorresponding author. Address: Oncology Centre, Box 193, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK.

Received 20 October 2008 ,Revised 3 March 2009 ,Accepted 4 March 2009.

References 

  1. Early Breast Cancer Trialists’ Collaborative Group. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet 2000;355:1757–70.
  2. Neal AJ, Torr M, Helyer S, Yarnold JR. Correlation of breast dose heterogeneity with breast size using 3D CT planning and dose–volume histograms. Radiother Oncol. 1995;34:210–218
  3. Al-Ghazal SK, Fallowfield L, Blamey RW. Does cosmetic outcome from treatment of primary breast cancer influence psychosocial morbidity?. Eur J Surg Oncol. 1999;25:571–573
  4. Webb S. The physical basis of IMRT and inverse planning. Br J Radiol. 2003;76:678–689
  5. Donovan E, Bleakley N, Denholm E, et al. Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol. 2007;82:254–264
  6. Pignol JP, Olivotto I, Rakovitch E, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol. 2008;26:2085–2092
  7. Coles C, Hoole A, Twyman N, Sycamore C, Burnet N, Wilson C. Innovative use of a laser camera for 3-dimensional breast radiotherapy planning. Clin Oncol. 2002;14:S11
  8. Hurkmans CW, Borger JH, Pieters BR, Russell NS, Jansen EP, Mijnheer BJ. Variability in target volume delineation on CT scans of the breast. Int J Radiat Oncol Biol Phys. 2001;50:1366–1372
  9. International Commission on Radiation Units and Measurements. Prescribing, recording, and reporting photon beam therapy. Bethesda, MD: International Commission on Radiation Units and Measurements; 1993.
  10. Coles C, Hoole A, Twyman N, Wilkinson J, Wilson C, Moody A. Forward-planned breast intensity modulated radiotherapy (IMRT): a novel method using a 3D laser camera. Breast Cancer Res Treat. 2003;82:S184
  11. Coles CE, Cash CJ, Treece GM, et al. High definition three-dimensional ultrasound to localise the tumour bed: a breast radiotherapy planning study. Radiother Oncol. 2007;84:233–241
  12. Burnet NG, Routsis DS, Murrell P, et al. A tool to measure radiotherapy complexity and workload: derivation from the basic treatment equivalent (BTE) concept. Clin Oncol (Royal College of Radiologists (Great Britain)). 2001;13:14–23
  13. Kestin LL, Sharpe MB, Frazier RC, et al. Intensity modulation to improve dose uniformity with tangential breast radiotherapy: initial clinical experience. Int J Radiat Oncol Biol Phys. 2000;48:1559–1568
  14. Zackrisson B, Arevarn M, Karlsson M. Optimized MLC-beam arrangements for tangential breast irradiation. Radiother Oncol. 2000;54:209–212
  15. Richmond ND, Turner RN, Dawes PJ, Lambert GD, Lawrence GP. Evaluation of the dosimetric consequences of adding a single asymmetric or MLC shaped field to a tangential breast radiotherapy technique. Radiother Oncol. 2003;67:165–170
  16. Donovan EM, Yarnold JR, Adams EJ, Morgan A, Warrington AP, Evans PM. An investigation into methods of IMRT planning applied to breast radiotherapy. Br J Radiol. 2008;81:311–322
  17. Nihei K, Mitsumori M, Ishigaki T, et al. Determination of optimal radiation energy for different breast sizes using CT-simulator [correction of simulator] in tangential breast irradiation. Breast Cancer (Tokyo, Japan). 2000;7:231–236
  18. Donovan EM, Johnson U, Shentall G, Evans PM, Neal AJ, Yarnold JR. Evaluation of compensation in breast radiotherapy: a planning study using multiple static fields. Int J Radiat Oncol Biol Phys. 2000;46:671–679
  19. Aref A, Thornton D, Youssef E, et al. Dosimetric improvements following 3D planning of tangential breast irradiation. Int J Radiat Oncol Biol Phys. 2000;48:1569–1574
  20. Donovan EM, Bleackley NJ, Evans PM, Reise SF, Yarnold JR. Dose-position and dose–volume histogram analysis of standard wedged and intensity modulated treatments in breast radiotherapy. Br J Radiol. 2002;75:967–973
  21. Jefferies S, Taylor A, Reznek R. Radiotherapy planning working party. Results of national survey of radiotherapy planning and delivery in the United Kingdom in 2007. Clin Oncol. 2009;21:204–217

PII: S0167-8140(09)00098-X

doi: 10.1016/j.radonc.2009.03.003

Radiotherapy & Oncology
Volume 92, Issue 1 , Pages 34-41 , July 2009