Radiotherapy & Oncology
Volume 91, Issue 1 , Pages 33-37, April 2009

Post-mastectomy radiation in large node-negative breast tumors: Does size really matter?

  • Scott R. Floyd

      Affiliations

    • Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    • Current address: Department of Radiation Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    • ,
  • Alphonse G. Taghian

      Affiliations

    • Breast Service, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Radiation Oncology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Received 2 December 2007; received in revised form 15 September 2008; accepted 19 September 2008. published online 09 February 2009.

Abstract 

Treatment decisions regarding local control can be particularly challenging for T3N0 breast tumors because of difficulty in estimating rates of local failure after mastectomy. Reports in the literature detailing the rates of local failure vary widely, likely owing to the uncommon incidence of this clinical situation. The literature regarding this clinical scenario is reviewed, including recent reports that specifically address the issue of local failure rates after mastectomy in the absence of radiation for large node-negative breast tumors.

Keywords: Breast cancer, T3N0, Post-mastectomy radiation therapy

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PII: S0167-8140(08)00517-3

doi:10.1016/j.radonc.2008.09.015

Radiotherapy & Oncology
Volume 91, Issue 1 , Pages 33-37, April 2009

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