Radiotherapy & Oncology
Volume 91, Issue 1 , Pages 49-53, April 2009

The impact of postmastectomy radiotherapy on local control in patients with invasive lobular breast cancer

  • Lindy A. Diepenmaat

      Affiliations

    • Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    • ,
  • Maurice J.C. van der Sangen

      Affiliations

    • Department of Radiotherapy, Catharina Hospital, Eindhoven, The Netherlands
    • ,
  • Lonneke V. van de Poll-Franse

      Affiliations

    • Eindhoven Cancer Registry, Eindhoven, The Netherlands
    • CoRPS – Center of Research on Psychology in Somatic Diseases, Department of Medical Psychology, Tilburg University, The Netherlands
    • ,
  • Mike W.P.M. van Beek

      Affiliations

    • Regional Institute of Pathology (PAMM), Eindhoven, The Netherlands
    • ,
  • Charles L.H. van Berlo

      Affiliations

    • Department of Surgery, VieCuri Medical Centre, Venlo, The Netherlands
    • ,
  • Ernest J.T. Luiten

      Affiliations

    • Department of Surgery, St Anna Hospital, Geldrop, The Netherlands
    • ,
  • Grard A.P. Nieuwenhuijzen

      Affiliations

    • Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands
    • ,
  • Adri C. Voogd

      Affiliations

    • Department of Epidemiology, Research Institute Growth and Development (GROW), Maastricht University, Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author. Address: Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

Received 28 April 2008; received in revised form 10 September 2008; accepted 23 September 2008. published online 24 October 2008.

Abstract 

Purpose

The aim of this population-based study was to examine the impact of postmastectomy radiotherapy on the risk of local recurrence in patients with invasive lobular breast cancer (ILC).

Methods

The population-based Eindhoven Cancer Registry was used to select all patients with ILC, who underwent mastectomy in five general hospitals in the southern part of the Netherlands between 1995 and 2002. Of the 499 patients 383 patients fulfilled the eligibility criteria. Of these patients, 170 (44.4%) had received postmastectomy radiotherapy. The median follow-up was 7.2 years. Fourteen patients (3.7%) were lost to follow-up.

Results

During follow-up 22 patients developed a local recurrence, of whom 4 had received postmastectomy radiotherapy. The 5-year actuarial risk of local recurrence was 2.1% for the patients with and 8.7% for the patients without postmastectomy radiotherapy. After adjustment for age at diagnosis, tumour stage and adjuvant systemic treatment, the patients who underwent postmastectomy radiotherapy were found to have a more than 3 times lower risk of local recurrence compared to the patients without (Hazard Ratio 0.30; 95% Confidence Interval: 0.10–0.89).

Conclusion

Local control is excellent for patients with ILC who undergo postmastectomy radiotherapy and significantly better than for patients not receiving radiotherapy.

Keywords: Breast carcinoma, Lobular type, Mastectomy, Radiotherapy, Local control

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PII: S0167-8140(08)00513-6

doi:10.1016/j.radonc.2008.09.012

Radiotherapy & Oncology
Volume 91, Issue 1 , Pages 49-53, April 2009

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