Radiotherapy & Oncology
Volume 90, Issue 1 , Pages 1-13, January 2009

Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: A systematic review

  • Birgitte V. Offersen

      Affiliations

    • Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
    • Corresponding Author InformationCorresponding author. Department of Oncology, Aarhus University Hospital, Nørrebrogade 44, bld. 5, DK-8000 Aarhus C, Denmark.
  • ,
  • Marie Overgaard

      Affiliations

    • Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
  • ,
  • Niels Kroman

      Affiliations

    • Department of Breast Surgery, Rigshospitalet, Denmark
  • ,
  • Jens Overgaard

      Affiliations

    • Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark

Received 5 May 2008; received in revised form 8 August 2008; accepted 13 August 2008. published online 10 September 2008.

Abstract 

New strategies for adjuvant radiotherapy of early breast cancer are being investigated in several phase III randomised trials at the present time. Accelerated partial breast irradiation (APBI) is a way to offer an early breast cancer patient, who has had breast conservative surgery, an adjuvant radiotherapy of short duration aimed at the tumour bed with a certain margin. The rationale of this strategy is that most local recurrences appear close to the tumorectomy cavity and a wish to spare the patient late radiation morbidity. This review discusses the background for APBI, the different techniques, and we highlight possible pitfalls using these techniques. A systematic overview of all phase I and II studies is provided. Patient selection for this therapy is pivotal and based on evidence from previous studies on patient/tumour characteristics and pattern of local recurrences we propose inclusion criteria for patients in APBI protocols.

Keywords: Accelerated partial breast irradiation, Early breast cancer, Adjuvant radiotherapy

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PII: S0167-8140(08)00434-9

doi:10.1016/j.radonc.2008.08.005

Refers to corrigendum:

  • Corrigendum to “Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: A systematic review” [Radiother. Oncol. 90 (2009) 1–13] , 27 May 2011

    Birgitte V. Offersen, Marie Overgaard, Niels Kroman, Jens Overgaard
    Radiotherapy & Oncology May 2011 (Vol. 99, Issue 2, Page 254)

Radiotherapy & Oncology
Volume 90, Issue 1 , Pages 1-13, January 2009