Radiotherapy & Oncology
Volume 88, Issue 2 , Pages 192-195 , August 2008

A novel concept of treatment of diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT)

  • Minoru Suzuki

      Affiliations

    • Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan
    • Corresponding Author InformationCorresponding author. Minoru Suzuki, Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University 2-1010, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
    • ,
  • Kazuo Endo

      Affiliations

    • Department of Pulmonary Medicine, Hyogo Prefectural Amaga-saki Hospital, Hyogo, Japan
    • ,
  • Hiroaki Satoh

      Affiliations

    • Department of Pulmonary Medicine, University of Tsukuba, Ibaraki, Japan
    • ,
  • Yoshinori Sakurai

      Affiliations

    • Radiation Medical Physics Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan
    • ,
  • Hiroaki Kumada

      Affiliations

    • Nuclear Science Institute, Japan Atomic Energy Agency (JAEA), Ibaraki, Japan
    • ,
  • Hiroyuki Kimura

      Affiliations

    • Department of Radiology, Hyogo Prefectural Amaga-saki Hospital, Hyogo, Japan
    • ,
  • Shinichiro Masunaga

      Affiliations

    • Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan
    • ,
  • Yuko Kinashi

      Affiliations

    • Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan
    • ,
  • Kenji Nagata

      Affiliations

    • Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan
    • ,
  • Akira Maruhashi

      Affiliations

    • Radiation Medical Physics Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan
    • ,
  • Koji Ono

      Affiliations

    • Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan

Received 10 March 2008 ,Revised 9 June 2008 ,Accepted 18 June 2008.

References 

  1. Coderre JA, Morris GM. The radiation biology of boron neutron capture therapy. Radiat Res. 1999;151:1–18
  2. Suzuki M, Sakurai Y, Masunaga S, et al. Feasibility of boron neutron capture therapy (BNCT) for malignant pleural mesothelioma from a viewpoint of dose distribution analysis. Int J Radiat Oncol Biol Phys. 2006;66:1584–1589
  3. Suzuki M, Sakurai Y, Hagiwara S, et al. First attempt of boron neutron capture therapy (BNCT) for hepatocellular carcinoma. Jpn J Clin Oncol. 2007;37:376–381
  4. Suzuki M, Sakurai Y, Masunaga S, et al. Preliminary experimental study of boron neutron capture therapy for malignant tumors spreading in thoracic cavity. Jap J Clin Oncol. 2007;37:245–249
  5. Wojnecki C, Green S. A preliminary comparative study of two treatment planning systems developed for boron neutron capture therapy: MacNCTPlan and SERA. Med Phys. 2002;29:1710–1715
  6. Kumada H, Yamamoto K, Matsumura A, et al. Verification of the computational dosimetry system in JAERI (JCDS) for boron neutron capture therapy. Phys Med Biol. 2004;49:3353–3365
  7. Aihara T, Hiratsuka J, Morita N, et al. First clinical case of boron neutron capture therapy for head and neck malignancies using 18F-BPA PET. Head Neck. 2006;28:850–855
  8. Mehta V. Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: pulmonary function, prediction, and prevention. Int J Radiat Oncol Biol Phys. 2005;63:5–24
  9. Willner J, Jost A, Baier K, Flentje M. A little to a lot or a lot to a little? An analysis of pneumonitis risk from dose–volume histogram parameters of the lung in patients with lung cancer treated with 3-D conformal radiotherapy. Strahlenther Onkol. 2003;179:548–556
  10. Sterman DH, Albelda SM. Advances in the diagnosis, evaluation, and management of malignant pleural mesothelioma. Respirology. 2005;10:266–283
  11. Chan MF, Chui CS, Song Y, et al. A novel radiation therapy technique for malignant pleural mesothelioma combining electrons with intensity-modulated photons. Radiother Oncol. 2006;79:218–223
  12. Sterzing F, Sroka-Perez G, Schubert K, et al. Evaluating target coverage and normal tissue sparing in the adjuvant radiotherapy of malignant pleural mesothelioma: helical tomotherapy compared with step-and-shoot IMRT. Radiother Oncol. 2008;86:251–257
  13. Vogelzang NJ, Rusthoven JJ, Symanowski J, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003;21:2636–2644
  14. de Graaf-Strukowska L, van der Zee J, van Putten W, Senan S. Factors influencing the outcome of radiotherapy in malignant mesothelioma of the pleura – a single-institution experience with 189 patients. Int J Radiat Oncol Biol Phys. 1999;43:511–516

PII: S0167-8140(08)00337-X

doi: 10.1016/j.radonc.2008.06.009

Radiotherapy & Oncology
Volume 88, Issue 2 , Pages 192-195 , August 2008

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