A novel concept of treatment of diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT)

Suzuki, Minoru; Endo, Kazuo; Satoh, Hiroaki; Sakurai, Yoshinori; Kumada, Hiroaki; Kimura, Hiroyuki; Masunaga, Shinichiro; Kinashi, Yuko; Nagata, Kenji; Maruhashi, Akira; Ono, Koji

doi:10.1016/j.radonc.2008.06.009

« Previous Next »Radiotherapy & Oncology
Volume 88, Issue 2 , Pages 192-195, August 2008

A novel concept of treatment of diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT)

Minoru Suzuki
- Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan
- Corresponding author. Minoru Suzuki, Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University 2-1010, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
Kazuo Endo
- Department of Pulmonary Medicine, Hyogo Prefectural Amaga-saki Hospital, Hyogo, Japan
Hiroaki Satoh
- Department of Pulmonary Medicine, University of Tsukuba, Ibaraki, Japan
Yoshinori Sakurai
- Radiation Medical Physics Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan
Hiroaki Kumada
- Nuclear Science Institute, Japan Atomic Energy Agency (JAEA), Ibaraki, Japan
Hiroyuki Kimura
- Department of Radiology, Hyogo Prefectural Amaga-saki Hospital, Hyogo, Japan
Shinichiro Masunaga
- Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan
Yuko Kinashi
- Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan
Kenji Nagata
- Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan
Akira Maruhashi
- Radiation Medical Physics Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan
Koji Ono
- Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan

Received 10 March 2008; received in revised form 9 June 2008; accepted 18 June 2008. published online 24 July 2008.

Abstract

Two patients, one with malignant pleural mesothelioma and one with a malignant short spindle cell tumor, received boron neutron capture therapy (BNCT). In each case, the tumors regressed or remained stable in size for 3–6 months following BNCT. No acute or late adverse events higher than grade 2 were observed.

Keywords: Boron neutron capture therapy, Thoracic tumor, Malignant pleura mesothelioma