Radiotherapy & Oncology
Volume 89, Issue 1 , Pages 51-56 , October 2008

Hypofractionated, palliative radiotherapy for advanced head and neck cancer

Received 28 February 2008 ,Revised 3 June 2008 ,Accepted 18 June 2008.

References 

  1. Bezjak A, Adam J, Panzarella T, et al. Radiotherapy for brain metastases: defining palliative response. Radiother Oncol. 2001;61:71–76
  2. Burns L, Chase D, Goodwin WJ. Treatment of patients with stage IV cancer: do the ends justify the means?. Otolaryngol Head Neck Surg. 1987;97:8–14
  3. Carvalho AL, Salvajoli JV, Kowalski LP. A comparison of radiotherapy or radiochemotherapy with symptomatic treatment alone in patients with advanced head and neck carcinomas. Eur Arch Otorhinolaryngol. 2000;257:164–167
  4. Chow E, Wu JS, Hoskin P, Coia LR, Bentzen SM, Blitzer PH. International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiother Oncol. 2002;64:275–280
  5. Corry J, Peters LJ, Costa ID, et al. The ‘QUAD SHOT’ – a phase II study of palliative radiotherapy for incurable head and neck cancer. Radiother Oncol. 2005;77:137–142
  6. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC). Int J Radiat Oncol Biol Phys. 1995;31:1341–1346
  7. Dobrowsky W, Naude J. Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancers. Radiother Oncol. 2000;57:119–124
  8. Forbes K. Palliative care in patients with cancer of the head and neck. Clin Otolaryngol Allied Sci. 1997;22:117–122
  9. Fu KK, Clery M, Ang KK, Byhardt RW, Maor MH, Beitler JJ. Randomized phase I/II trial of two variants of accelerated fractionated radiotherapy regimens for advanced head and neck cancer: results of RTOG 88-09. Int J Radiat Oncol Biol Phys. 1995;32:589–597
  10. Grau C, Prakash Agarwal J, Jabeen K, et al. Radiotherapy with or without mitomycin c in the treatment of locally advanced head and neck cancer: results of the IAEA multicentre randomised trial. Radiother Oncol. 2003;67:17–26
  11. Hayter CR, Huff-Winters C, Paszat L, Youssef YM, Shelley WE, Schulze K. A prospective trial of short-course radiotherapy plus chemotherapy for palliation of dysphagia from advanced esophageal cancer. Radiother Oncol. 2000;56:329–333
  12. Henk JM, James KW. Comparative trial of large and small fractions in the radiotherapy of head and neck cancer. Clin Radiol. 1978;29:611–616
  13. Hodson DI, Bruera E, Eapen L, et al. The role of palliative radiotherapy in advanced head and neck cancer. Can J Oncol. 1996;6:54–60
  14. Kowalski LP, Carvalho AL. Natural history of untreated head and neck cancer. Eur J Cancer. 2000;36:1032–1037
  15. Lucente FE. Treatment of head-and-neck carcinoma with noncurative intent. Am J Otolaryngol. 1994;15:99–102
  16. Mohanti BK, Umapathy H, Bahadur S, Thakar A, Pathy S. Short course palliative radiotherapy of 20Gy in 5 fractions for advanced and incurable head and neck cancer: AIIMS study. Radiother Oncol. 2004;71:275–280
  17. Percarpio B, Fischer JJ. Irradiation of advanced head and neck cancer with large daily fractions. Preliminary results of a prospectively randomized clinical trial. Radiology. 1976;121:489–490
  18. Porceddu SV, Rosser B, Burmeister BH, et al. Hypofractionated radiotherapy for the palliation of advanced head and neck cancer in patients unsuitable for curative treatment-hypo trial. Radiother Oncol. 2007;85:456–462
  19. Rao DN, Shroff PD, Chattopadhyay G, Dinshaw KA. Survival analysis of 5595 head and neck cancers – results of conventional treatment in a high-risk population. Br J Cancer. 1998;77:1514–1518
  20. Senn HJ, Glaus A. Supportive Care in Cancer – 15 years thereafter. Support Care Cancer. 2002;10:8–12
  21. Talapatra K, Gupta T, Agarwal J, Laskar S, Shrivastava S, Dinshaw K. Palliative radiotherapy in head and neck cancers: evidence based review. Indian J Palliat Care. 2006;12:44–50
  22. Trotti A, Pajak TF, Gwede CK, et al. TAME: development of a new method for summarising adverse events of cancer treatment by the Radiation Therapy Oncology Group. Lancet Oncol. 2007;8:613–624
  23. Vikram B. Cancers of the head and neck region in developing countries. Radiother Oncol. 2003;67:1–2
  24. Weissberg JB, Pillsbury H, Sasaki CT, Son YH, Fischer JJ. High fractional dose irradiation of advanced head and neck cancer. Implications for combined radiotherapy and surgery. Arch Otolaryngol. 1983;109:98–102

PII: S0167-8140(08)00335-6

doi: 10.1016/j.radonc.2008.06.007

Radiotherapy & Oncology
Volume 89, Issue 1 , Pages 51-56 , October 2008

Article Tools

* Image Usage & Resolution