Radiotherapy & Oncology
Volume 89, Issue 1 , Pages 33-37 , October 2008

Long-term results of a prospective multicenter phase II study to preserve the larynx function using concomitant boost radiochemotherapy with Carboplatin

  • Volker Rudat

      Affiliations

    • Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    • Department of Radiation Oncology, Saad Specialist Hospital, Al-Khobar, Saudi Arabia
    • Corresponding Author InformationCorresponding author. Volker Rudat, Department of Radiation Oncology, Saad Specialist Hospital, P.O. Box 30353, Al-Khobar 31952, Saudi Arabia.
    • ,
  • Hans Eckel

      Affiliations

    • Department of Head and Neck Surgery, Landeskrankenhaus Klagenfurt, Klagenfurt, Austria
    • ,
  • Peter Volling

      Affiliations

    • Department of Head and Neck Surgery, Evangelisches Krankenhaus, Oldenburg, Germany
    • ,
  • Michael Schröder

      Affiliations

    • Department of Head and Neck Surgery, Staedtisches Krankenhaus Kassel, Kassel, Germany
    • ,
  • Susanne Staar

      Affiliations

    • Department of Radiation Oncology, Klinikum Bremen-Mitte, Bremen, Germany
    • ,
  • Frank Wallner

      Affiliations

    • Department of Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    • ,
  • Michael Wannenmacher

      Affiliations

    • Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    • ,
  • Andreas Dietz

      Affiliations

    • Department of Radiation Oncology, Saad Specialist Hospital, Al-Khobar, Saudi Arabia
    • Department of Head and Neck Surgery, University of Leipzig, Leipzig, Germany

Received 3 February 2008 ,Revised 19 May 2008 ,Accepted 18 June 2008.

References 

  1. Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst. 1996;88:890–899
  2. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Laryngeal Cancer Study Group. N Engl J Med 1991;324:1685–90.
  3. Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet. 2000;355:949–955
  4. Fu KK, Pajak TF, Trotti A, et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys. 2000;48:7–16
  5. Rudat V, Dietz A, Nollert J, et al. Acute and late toxicity, tumour control and intrinsic radiosensitivity of primary fibroblasts in vitro of patients with advanced head and neck cancer after concomitant boost radiochemotherapy. Radiother Oncol. 1999;53:233–245
  6. Rudat V, Dietz A, Schramm O, et al. Prognostic impact of total tumor volume and hemoglobin concentration on the outcome of patients with advanced head and neck cancer after concomitant boost radiochemotherapy. Radiother Oncol. 1999;53:119–125
  7. Dietz A, Nollert J, Eckel H, et al. Organ preservation in advanced laryngeal and hypopharyngeal carcinoma by primary radiochemotherapy. Results of a multicenter phase II study. Hno. 2002;50:146–154
  8. Forastiere AA, Goepfert H, Maor M, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349:2091–2098
  9. Forastiere AA, Maor M, Weber RS, et al. Long-term results of Intergroup RTOG 91-11: a phase III trial to preserve the larynx–induction cisplatin/5-FU and radiation therapy versus concurrent cisplatin and radiation therapy versus radiation therapy. J Clin Oncol, 2006 ASCO Annual Meeting Proceedings Part I. 2006;24.
  10. de la Vega FA, Garcia RV, Dominguez D, et al. Hyperfractionated radiotherapy and concomitant cisplatin for locally advanced laryngeal and hypopharyngeal carcinomas: final results of a single institutional program. Am J Clin Oncol. 2003;26:550–557
  11. Hanna E, Alexiou M, Morgan J, et al. Intensive chemoradiotherapy as a primary treatment for organ preservation in patients with advanced cancer of the head and neck: efficacy, toxic effects, and limitations. Arch Otolaryngol Head Neck Surg. 2004;130:861–867
  12. Mancuso AA, Mukherji SK, Schmalfuss I, et al. Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma. J Clin Oncol. 1999;17:631–637

PII: S0167-8140(08)00331-9

doi: 10.1016/j.radonc.2008.06.005

Radiotherapy & Oncology
Volume 89, Issue 1 , Pages 33-37 , October 2008

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