Radiotherapy & Oncology
Volume 88, Issue 2 , Pages 183-191 , August 2008

Boron neutron capture therapy (BNCT) for glioblastoma multiforme: A phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)

  • Roger Henriksson

      Affiliations

    • Department of Radiation Sciences & Oncology, Umeå University, Umeå, Sweden
    • Corresponding Author InformationCorresponding author. Roger Henriksson, Department of Radiation Sciences & Oncology, Umeå University, Umeå S-901 85, Sweden.
    • ,
  • Jacek Capala

      Affiliations

    • Studsvik Medical Co., Nyköping, Sweden
    • Unit for Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    • ,
  • Annika Michanek

      Affiliations

    • Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden
    • ,
  • Sten-Åke Lindahl

      Affiliations

    • Department of Oncology, Karlstad Central Hospital, Sweden
    • ,
  • Leif G. Salford

      Affiliations

    • Department of Neurosurgery and Radiation Physics, Lund University Hospital, Lund, Sweden
    • ,
  • Lars Franzén

      Affiliations

    • Department of Radiation Sciences & Oncology, Umeå University, Umeå, Sweden
    • ,
  • Erik Blomquist

      Affiliations

    • Department of Radiation Oncology, Uppsala University Hospital, Uppsala, Sweden
    • ,
  • Jan-Erik Westlin

      Affiliations

    • Department of Oncology, Central Hospital, Eskilstuna, Sweden
    • ,
  • A. Tommy Bergenheim

      Affiliations

    • Department of Neurosurgery, Umeå University, Umeå, Sweden

Received 5 September 2005 ,Revised 7 February 2008 ,Accepted 21 February 2008.

References 

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  2. Barth RF. A critical assessment of boron neutron capture therapy: an overview. J Neurooncol. 2003;62:61–74
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  5. Bauer W, Micca P, White B. A rapid method for the direct analysis of boron in whole blood by atomic emission spectroscopy. Proceeding of the fifth international symposium on neutron capture therapy, columbus, OH. September 14–17 1992. In:  Soloway AH,  Barth RF,  Carpenter DE editor. Advances in Neutron Capture Therapy. New York: Plenum Pres; 1993;p. 403–407
  6. Bergenheim AT, Capala J, Roslin M, Henriksson R. Distribution of BPA and metabolic assessment in glioblastoma patients during BNCT treatment: a microdialysis study. J Neurooncol. 2005;71:287–293
  7. Busse M, Harling OK, Palmer MR, et al. A critical examination of the results from the Harvard-MIT NCT program phase I clinical trial of neutron capture therapy for intracranial disease. J Neurooncol. 2003;62:111–121
  8. Capala J, Stenstam BH, Sköld K, et al. Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden. J Neurooncol. 2003;62:133–144
  9. Chanana AD, Capala J, Chadha M, et al. Boron neutron capture therapy for glioblastoma multiforme: interim results from the phase I/II dose-escalation studies. Neurosurgery. 1999;44:1182–1193
  10. Chandra S, Smith DR, Morrisonm GH. Subcellular imaging by dynamic SIMS ion microscopy. Anal Chem. 2000;72:104A–114A
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  12. Coderre JA, Morris GM. The radiation biology of boron neutron capture therapy. Radiat Res. 1999;151:1–18
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  15. Henriksson R, Malmström A, Bergström P, Bergh G, Trojanowski T, Andreasson L, et al. High grade astrocytoma treated concomitantly with estramustine and radiotherapy. J Neuro-oncol. 2005;
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  17. Joensuu H, Kankaanranta L, Seppälä T, et al. Boron neutron capture therapy of brain tumours: clinical trials at the Finnish facility using boronophenylalanine. J Neurooncol. 2003;62:23–34
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☆ The study was conducted as a project within the Swedish Brain Tumour Study Group.

PII: S0167-8140(08)00114-X

doi: 10.1016/j.radonc.2006.04.015

Radiotherapy & Oncology
Volume 88, Issue 2 , Pages 183-191 , August 2008

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