Radiotherapy & Oncology
Volume 87, Issue 1 , Pages 55-58, April 2008

Correlation of intra-tumour heterogeneity on 18F-FDG PET with pathologic features in non-small cell lung cancer: A feasibility study

  • Angela van Baardwijk

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW , University Hospital Maastricht, Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author. Angela van Baardwijk, Department of Radiation Oncology (MAASTRO), GROW, University Hospital Maastricht, Dr. Tanslaan 12, 6229 ET Maastricht, The Netherlands.
    • ,
  • Geert Bosmans

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW , University Hospital Maastricht, Maastricht, The Netherlands
    • ,
  • Robert Jan van Suylen

      Affiliations

    • Department of Pathology , University Hospital Maastricht, Maastricht, The Netherlands
    • ,
  • Marinus van Kroonenburgh

      Affiliations

    • Department of Nuclear Medicine , University Hospital Maastricht, Maastricht, The Netherlands
    • ,
  • Monique Hochstenbag

      Affiliations

    • Department of Respiratory Medicine , University Hospital Maastricht, Maastricht, The Netherlands
    • ,
  • Gijs Geskes

      Affiliations

    • Department of Cardiothoracic Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    • ,
  • Philippe Lambin

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW , University Hospital Maastricht, Maastricht, The Netherlands
    • ,
  • Dirk De Ruysscher

      Affiliations

    • Department of Radiation Oncology (MAASTRO), GROW , University Hospital Maastricht, Maastricht, The Netherlands

Received 12 September 2007; received in revised form 21 January 2008; accepted 3 February 2008. published online 07 March 2008.

Abstract 

We evaluated the feasibility to correlate intra-tumour heterogeneity as visualized on 18F-FDG PET with histology for NSCLC. For this purpose we used an ex-vivo model. The procedure was feasible in all operated patients. We have shown that this method is suitable for correlating intra-tumour heterogeneity in tracer uptake with histology.

Keywords: NSCLC, 18F-FDG PET, Pathology, Intra-tumour heterogeneity, Ex-vivo model

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PII: S0167-8140(08)00088-1

doi:10.1016/j.radonc.2008.02.002

Radiotherapy & Oncology
Volume 87, Issue 1 , Pages 55-58, April 2008

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