Radiotherapy & Oncology
Volume 87, Issue 3 , Pages 318-325 , June 2008

Intraoperative radiotherapy in pancreatic cancer: A systematic review

  • Alberto Ruano-Ravina

      Affiliations

    • Galician Agency for Health Technology Assessment, Galician Health Authority, Santiago de Compostela, Spain, Spain
    • Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain, Spain
    • CIBER de Epidemiologı´a y Salud Pública, Spain, Spain
    • Corresponding Author InformationCorresponding author. Alberto Ruano-Ravina, Agencia de Evaluación de Tecnologı´as Sanitarias de Galicia, Consellerı´a de Sanidade, Edif Administrativo de San Lázaro, San Lázaro s/n, 15781 Santiago de Compostela, Spain.
  • ,
  • Raquel Almazán Ortega

      Affiliations

    • Research Unit, Ourense Hospital Complex, Ourense, Spain, Spain
  • ,
  • Ferrran Guedea

      Affiliations

    • Department of Radiation Oncology, University of Barcelona, Spain

Received 14 September 2007 ,Revised 3 December 2007 ,Accepted 7 December 2007.

References 

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108
  2. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA Cancer J Clin. 2000;50:7–33
  3. National Cancer Institute. Pancreatic Cancer (PDQ): treatment. 2007 15.03.2007 [cited 16.04.2007]. Available from: www.cancer.gov.
  4. Yeo CJ, Cameron JL, Sohn TA, Lillemoe KD, Pitt HA, Talamini MA, et al. Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg. 1997;226:248–257[Discussion 57–60]
  5. Conlon KC, Klimstra DS, Brennan MF. Long-term survival after curative resection for pancreatic ductal adenocarcinoma Clinicopathologic analysis of 5-year survivors. Ann Surg. 1996;223:273–279
  6. Trede M, Schwall G, Saeger HD. Survival after pancreatoduodenectomy 118 consecutive resections without an operative mortality. Ann Surg. 1990;211:447–458
  7. Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg. 1993;165:68–72[Discussion 3]
  8. Lim JE, Chien MW, Earle CC. Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients. Ann Surg. 2003;237:74–85
  9. Wagner M, Redaelli C, Lietz M, Seiler CA, Friess H, Buchler MW. Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg. 2004;91:586–594
  10. Yamaguchi K, Nakamura K, Kobayashi K, Nakano K, Koniomi H, Mizumoto K, et al. ERT following IORT improves survival of patients with resectable pancreatic cancer. Hepatogastroenterology. 2005;52:1244–1249
  11. Radioterapia Intraoperatoria. Informe de evaluación no 22: Agencia de Evaluación de Tecnologı´as Sanitarias. Instituto de Salud Carlos III. Ministerio de Sanidad y Consumo; 1999.
  12. Sindelar WF, Kinsella TJ. Normal tissue tolerance to intraoperative radiotherapy. Surg Oncol Clin N Am. 2003;12:925–942
  13. Harris RP, Helfand M, Woolf SH, Lohr KN, Mulrow CD, Teutsch SM. Current methods of the U.S. Preventive Services Task Force: a review of the process. Am J Prev Med. 2001;20:31–45
  14. Hiraoka T, Kanemitsu K. Value of extended resection and intraoperative radiotherapy for resectable pancreatic cancer. World J Surg. 1999;23:930–936
  15. Takamori H, Hiraoka T, Kanemitsu K, Tsuji T, Hamada C, Baba H. Identification of prognostic factors associated with early mortality after surgical resection for pancreatic cancer – under-analysis of cumulative survival curve. World J Surg. 2006;30:213–218
  16. O’Connor JK, Sause WT, Hazard LJ, Belnap LP, Noyes RD. Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma. Int J Radiat Oncol Biol Phys. 2005;63:1060–1066
  17. Okamoto A, Matsumoto G, Tsuruta K, Baba H, Karasawa K, Kamisawa T, et al. Intraoperative radiation therapy for pancreatic adenocarcinoma: the Komagome Hospital experience. Pancreas. 2004;28:296–300
  18. Reni M, Panucci MG, Ferreri AJ, Balzano G, Passoni P, Cattaneo GM, et al. Effect on local control and survival of electron beam intraoperative irradiation for resectable pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys. 2001;50:651–658
  19. Ma HB, Di ZL, Wang XJ, Kang HF, Deng HC, Bai MH. Effect of intraoperative radiotherapy combined with external beam radiotherapy following internal drainage for advanced pancreatic carcinoma. World J Gastroenterol. 2004;10:1669–1771
  20. Sunamura M, Karasawa K, Okamoto A, Ogata Y, Nemoto K, Hosotani R, et al. Phase III trial of radiosensitizer PR-350 combined with intraoperative radiotherapy for the treatment of locally advanced pancreatic cancer. Pancreas. 2004;28:330–334
  21. Mohiuddin M, Regine WF, Stevens J, Rosato F, Barbot D, Biermann W, et al. Combined intraoperative radiation and perioperative chemotherapy for unresectable cancers of the pancreas. J Clin Oncol. 1995;13:2764–2768
  22. Ihse I, Andersson R, Ask A, Ewers SB, Lindell G, Tranberg KG. Intraoperative radiotherapy for patients with carcinoma of the pancreas. Pancreatology. 2005;5:438–442
  23. Furuse J, Kinoshita T, Kawashima M, Ishii H, Nagase M, Konishi M, et al. Intraoperative and conformal external-beam radiation therapy with protracted 5-fluorouracil infusion in patients with locally advanced pancreatic carcinoma. Cancer. 2003;97:1346–1352
  24. Takahashi S, Aiura K, Saitoh J, Hayatsu S, Kitajima M, Ogata Y. Treatment strategy for pancreatic head cancer: pylorus-preserving pancreatoduodenectomy, intraoperative radiotherapy and portal catheterization. Digestion. 1999;60:130–134
  25. Kasperk R, Klever P, Andreopoulos D, Schumpelick V. Intraoperative radiotherapy for pancreatic-carcinoma. Br J Surg. 1995;82:1259–1261
  26. Hiraoka T, Uchino R, Kanemitsu K, Toyonaga M, Saitoh N, Nakamura I, et al. Combination of intraoperative radiation with resection of cancer of the pancreas. Int J Pancreatol. 1990;7:201–207
  27. Abe M, Takahashi M, Yabumoto E, Onoyama Y, Torizuka K. Techniques, indications and results of intraoperative radiotherapy of Advanced Cancers. Radiology. 1975;116:693–702

PII: S0167-8140(07)00654-8

doi: 10.1016/j.radonc.2007.12.002

Radiotherapy & Oncology
Volume 87, Issue 3 , Pages 318-325 , June 2008