Radiotherapy & Oncology
Volume 87, Issue 3 , Pages 343-349 , June 2008

Short-course preoperative radiotherapy with delayed surgery in rectal cancer – A retrospective study

  • Calin Radu

      Affiliations

    • Department of Oncology, Radiology and Clinical Immunology, and
    • Corresponding Author InformationCorresponding author. Calin Radu, Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.
    • ,
  • Åke Berglund

      Affiliations

    • Department of Oncology, Radiology and Clinical Immunology, and
    • ,
  • Lars Påhlman

      Affiliations

    • Department of Surgery, Uppsala University, Sweden
    • ,
  • Bengt Glimelius

      Affiliations

    • Department of Oncology, Radiology and Clinical Immunology, and
    • Department of Pathology and Oncology, Karolinska Institutet, Stockholm, Sweden

Received 19 October 2007 ,Revised 23 November 2007 ,Accepted 25 November 2007.

References 

  1. Frykholm G, Glimelius B, Påhlman L. Preoperative irradiation with and without chemotherapy (MFL) in the treatment of primary non-resectable adenocarcinoma of the rectum. Results from two consecutive studies. Eur J Cancer Clin Oncol. 1989;25:1535–1541
  2. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731–1740
  3. Sebag-Montefiore D. Developments in the use of chemoradiotherapy in rectal cancer. Colorectal Dis. 2006;8:14–17
  4. Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 1997;336:980–7.
  5. Kapiteijn E, Marijnen CAM, Nagtegaal ID, et al. Preoperative radiotherapy in combination with total mesorectal excision improves local control in resectable rectal cancer. Report from a multicenter randomized trial. New Engl J Med. 2001;345:638–646
  6. Peeters KCMJ, Marijnen CAM, Nagtegaal ID, et al. For the Dutch Colorectal Cancer Group The TME trial after a median follow-up of 5 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg. 2007;246:693–701
  7. Glimelius B, Grönberg H, Järhult J, Wallgren A, Cavallin-ståhl E. A systematic overview of radiation therapy effects in rectal cancer. Acta Oncol. 2003;42:476–492
  8. Glimelius B. Rectal cancer irradiation. Long course, short course or something else?. Acta Oncol. 2006;45:1013–1017
  9. Gerard JP, Conroy T, Bonnetain F, et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol. 2006;24:4620–4625
  10. Bosset JF, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006;355:1114–1123
  11. Widder J, Herbst F, Scheithauer W. Preoperative sequential short-term radiotherapy plus chemotherapy can induce complete remission in T3N2 rectal cancer. Acta Oncol. 2005;44:921–923
  12. Sørbye H, Glimelius B, Berglund Å, et al. Multicentre phase II study of Nordic 5-fluorouracil/leucovorin bolus schedule combined with oxaliplatin (FLOX) as first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2004;22:31–38
  13. de Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 2000;18:2938–2947
  14. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al. Long-term results of a randomised trial comparing preoperative short-course radiotherapy vs preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg. 2006;93:1215–1223
  15. Desch CE, Benson AB, Smith TJ, et al. Recommended colorectal cancer surveillance guidelines by the American Society of Clinical Oncology. J Clin Oncol. 1999;17:1312–1321
  16. Braendengen M, Tveit KM, Berglund Å, et al. A randomized phase III study (LARCS) comparing preoperative radiotherapy alone versus chemoradiotherapy in non-resectable rectal cancer. Eur J Cancer 2005; ECCO 13. Abstr 612.
  17. Courdi A. Fractionation sensitivity and equivalent doses. Commenting the Editorial by Glimelius. Acta Oncol. 2007;46:395–396[author reply 396]
  18. Glimelius B, Isacsson U. In reply to Dr. Courdi. Acta Oncol. 2007;46:396
  19. Smith N, Brown G. Preoperative staging of rectal cancer. Acta Oncol. 2008;47:1–12

PII: S0167-8140(07)00627-5

doi: 10.1016/j.radonc.2007.11.025

Radiotherapy & Oncology
Volume 87, Issue 3 , Pages 343-349 , June 2008

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