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Radiotherapy & Oncology
Volume 81, Issue 2
, Pages 130-135
, November 2006
Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice
References
- . Radiobiological considerations in the design of clinical trials. Radiother Oncol. 1994;32:1–11
- . Aerobic glycolysis by proliferating cells: protection against oxidative stress at the expense of energy yield. J Bioenerg Biomembr. 1997;29:355–364
- Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;51:349–353
- . Why do cancers have high aerobic glycolysis?. Nat Rev Cancer. 2004;4:891–899
- . Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Res. 2002;62:3909–3913
- Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood. 2006;107:2013–2021
- Differentiation status of human squamous cell carcinoma xenografts does not appear to correlate with the repopulation capacity of clonogenic tumour cells during fractionated irradiation. Int J Radiat Biol. 2004;80:719–727
- . Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst. 2001;93:266–276
- Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors. Radiother Oncol. 2004;70:91–97
- . Control of glycolysis in vertebrate skeletal muscle during exercise. Am J Physiol. 1996;270:R821–R829
- Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2005;62:20–31
- 2-Deoxy-d-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Res. 2003;63:3413–3417
- . Pyruvate: metabolic protector of cardiac performance. Proc Soc Exp Biol Med. 2000;223:136–148
- . Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging. Histochem J. 1993;25:407–420
- Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas. Radiother Oncol. 2003;67:35–44
- Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma. J Neurooncol. 2005;71:173–180
- Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging. Clin Cancer Res. 2004;10:2245–2252
- . HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med. 2002;8:S62–S67
- . The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955;9:539–549
- Comparison of different methods of CAIX quantification in relation to hypoxia in three human head and neck tumor lines. Radiother Oncol. 2005;76:194–199
- Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?. J Cancer Res Clin Oncol. 2003;129:321–326
- . Lactate: mirror and motor of tumor malignancy. Semin Radiat Oncol. 2004;14:267–274
- . Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology. Curr Med Chem. 2004;11:2195–2204
- High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res. 2000;60:916–921
- Comparison of magnetic resonance spectroscopy and perfusion-weighted imaging in presurgical grading of oligodendroglial tumors. Neurosurgery. 2005;56:919–926
- Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?. Radiother Oncol. 2005;76:206–212
- . Cancer metabolism: facts, fantasy, and fiction. Biochem Biophys Res Commun. 2004;313:459–465
☆ Financial support: This investigation was supported by grants of the Deutsche Forschungsgemeinschaft to W.M.K. (Mu 576/14-1) and to M.B. and D.Z. (Ba 1433/4-2).
PII: S0167-8140(06)00374-4
doi: 10.1016/j.radonc.2006.08.012
© 2006 Elsevier Ireland Ltd. All rights reserved.
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Radiotherapy & Oncology
Volume 81, Issue 2
, Pages 130-135
, November 2006
