On the dose to a moving target while employing different IMRT delivery mechanisms
Received 24 October 2006; received in revised form 26 January 2007; accepted 13 February 2007. published online 12 March 2007.
Abstract
Background and purposes
To compare the temporal uniformity in dose delivered to a moving target for various intensity modulation radiotherapy (IMRT) modalities: solid intensity modulator (SIM), segmented multi-leaf collimator (SMLC), and dynamic multi-leaf collimator (DMLC).
Materials and methods
Two separate four-dimensional computed tomography data sets were obtained. Tumor motion kernels and motion envelopes were determined from composite positions of the tumor in various phases of the breathing cycle. Treatment plans were created for an unmodulated open field, SIM, SMLC, and DMLC. The motion envelope was treated as a static target volume. A robotic apparatus equipped with a diode array simulated the tumor motion in the plane of the beam’s eye view (BEV). Radiation was delivered to the moving target over ten trials for each modality. The average coefficient of variation (CV) was determined for each beam angle.
Results
The CV ranged from 0.09% to 0.15%, 0.23% to 3.14%, 1.14% to 5.51%, and 3.83% to 8.25% for the unmodulated open field, SIM, SMLC, and DMLC modalities, respectively. With gating, the CV was 0.23% to 2.31%, 0.31% to 2.97%, and 0.7% to 4.67% for SIM, SMLC, and DMLC, respectively.
Conclusion
SIM consistently provided the most temporally uniform dose to the moving target while DMLC provided the least. The SMLC and DMLC CV improved with gated delivery.
Corresponding author. Wolfgang A. Tomé, Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, K4/344 CSC, 600 Highland Avenue, Madison, WI 53792, USA.
ABSTRACT